It is what all the cool kids are playing.
Never heard of it ;)
I have it, and have yet to start it.
Just finished with a 60 lvl character, siding with the Minutemen playing on normal and spending way too much time in Power Armor, so I rarely died. Going to start a new character on hard difficulty tonight playing without companions (they are a pain in most cases) and limiting power armor to times when it is pretty much required to survive. Plan to ignore the Minutemen stuff and side with a different faction and spend less time building other settlements. It's fun building stuff but certain resources are a pain to get and I ended up using a few of the glitches to duplicate items. Also the settlers are very needy.
Hoarders: Fallout edition. I had made some large buildings in the past but have decided to make my home base simple and easy to track my goodies. Except for the end of the video. Pretty much had to use all the copper in Boston, 12 Large Generators and 120 light boxes.
! No longer available (http://www.youtube.com/watch?v=g1kFjlDRKno#)